![]() ![]() Humans Iris, physiopathology Mesencephalon, physiopathology Neurosyphilis, complications Neurosyphilis, diagnosis Pupil Disorders, diagnosis Pupil Disorders, etiology Pupil Disorders, physiopathology Reflex, Pupillary, physiology Visual Pathways, physiopathology Until better evidence settles the localization of the AR pupil, it is appropriate to screen patients with bilateral tonic pupils for syphilis. If segmental iris sphincter palsy is found and the light-near dissociation has tonic features, one must conclude that the mechanism of the pupil disorder is a ciliary (peripheral) rather than a midbrain (central) denervation. Resolving the issue about the location of the syphilitic lesion that produces the AR pupil will depend on careful examination of patients with techniques designed to disclose segmental palsy of the iris. However, lesions in this region have not been reliably demonstrated in syphilis. ![]() Because the AR pupil lacks these features, it has been attributed to a dorsal midbrain lesion that interrupts the pupillary light reflex pathway but spares the more ventral pupillary near reflex pathway. Such features are considered typical of the light-near dissociation of Adie syndrome and of neuropathic tonic pupils, where damage to the ciliary ganglion or ciliary nerves is believed to be the mechanism. Most descriptions of the AR pupil do not mention segmental iris sphincter constriction, or slow, sustained constriction with a near vision effort. Argyll Robertson (AR) pupil has been defined as a pupil that is small and constricts poorly to direct light but briskly when a target within reading distance is viewed ("light-near dissociation"). Neuro-opthalmology Unit, Department of Opthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, USA. © North American Neuro-Ophthalmology Society Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890 Neuro-ophthalmology Virtual Education Library: NOVEL Journal of Neuro-Ophthalmology, June 2006, Volume 14, Issue 2 ![]()
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